李静

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李静 博士

我校教授,博士生导师

Jing Li, Ph.D.
Professor, Capital Normal University, Beijing, China

Phone:010-68901692
E-mail:
jing_li@ mail.cnu.edu.cn



招生方向:细胞

研究方向:蛋白质修饰


教育经历    

Education

2006              耶鲁大学分子、细胞及发育生物学系,博士 (导师:G. Shirleen Roeder, 美国科学院院士)

Ph. D., Molecular, Cellular and Developmental Biology, Yale University

2001             耶鲁大学分子、细胞及发育生物学系,硕士    

M. S., Molecular, Cellular and Developmental Biology, Yale University

1999             北京大学永利yl8886官方网站,学士    

B. S., College of Life Sciences, Peking University, China

     

荣誉    

Awards

2023             细胞生物学实验教材科学出版社第二批“十四五”规划教材    

2023             分子细胞生物学-首师大研究生课程思政优秀课程、优秀课程思政案例    

2021             细胞生物学-首批首师大课程思政示范课程    

2020             细胞生物学-首批国家级一流本科课程    

2019             细胞生物学-首批北京市优质本科课程    

2019             首批北京市高校优秀专业课主讲教师    

2019             我校2019届本科生毕业论文(设计)优秀指导教师    

2018             我校优秀主讲教师    

2017             北京市首届高等学校青年教学名师    

2017             我校优秀教师    

2017             我校最受学生喜爱导师    

2017             我校十大影响力师门    

2017             我校优秀主讲教师    

2016             北京市教委市属高校“创想杯”多媒体课件制作与微课程应用大奖赛三等奖    

2016             我校优秀主讲教师    

2015             教育部全国高校教师网络培训中心主办全国高校微课教学比赛教学设计奖作品:《细胞周期》

2015             我校优秀主讲教师    

2012             北京市高等教育教学成果奖一等奖(排名第三)    

2011             我校首届青年教师优秀教学奖    

2011             我校本科生毕业论文(设计)优秀指导教师    

2011             第七届北京市青年教师教学基本功比赛二等奖    

2010             霍英东教育基金会第十二届高等院校青年教师奖三等奖    

2009             我校青年教师教学基本功竞赛一等奖,最佳教案奖    

2007             北京市科技新星    

1999-2006    耶鲁大学━香港范氏奖学金 Fan Fellowship    

1998             北京大学光华奖奖学金    

     

工作经历    

Professional Experience

2018.1-             我校教授    Professor, CNU

2019-2022           我校生物科学专业负责人    

2009-2019           我校生科院细胞生物学教学团队队长    Director, Cell Biology Teaching Group, CNU

2008.9-2012.12    我校生科院院长助理    Dean Assistant, College of Life Sciences, CNU                     

2008.1-2017.12    我校副教授    Associate Professor, CNU

2007.5-2007.12    我校讲师    Assistant Professor, CNU

2006.4-2006.7      耶鲁大学分子、细胞及发育生物学系,博士后    Postdoctoral Associate, MCDB, Yale University


教材    

1李静,印莉萍,于荣, 《细胞生物学数字课程》, 高等教育出版社,2019ISBN978-7-89510-559-1

2.印莉萍,李静,于荣,《细胞生物学实验技术教程》(第四版),科学出版社,2015 ISBN978-7-03-044357-1

3.许兴智,佟伟民,李静,杨跃,丛羽生, 《癌症的分子基础》, 科学出版社,2011,978-7-0-303160-7

     

学术兼职    

2023        国家重点研发计划会评专家

2022        国家重点研发计划青年科学家项目函评专家    

2021-2025     中国生物物理学会糖生物学分会委员会委员    

2021           教育部全国优秀教材函评专家,国家级一流本科课程函评专家    

2021        国自然优青函评专家    

2020        国自然生命科学部交叉融合科学处函评专家    

2020        上海嘉会医疗,顾问    

2019-2024    苏州生物医药创新中心,学术委员会委员    

2019-       教育部学位中心函评专家    

2019        国自然生物二处、交叉融合科学处函评专家    

2017-            《中国生物化学与分子生物学报》英文编辑    

     

参与审稿的学术期刊    

Nature Chemical Biology, Nucleic Acids Research, Trends in Pharmacological Sciences, Cell Death & Discovery, Frontiers in Pharmacology, Journal of Genetics and Genomics, Frontiers in Genetics, Pharmaceuticals, Frontiers in Oncology, Cell Cycle, Scientific Reports Cancer Medicine Medical Research Archives Journal of Cancer Biology & Research, 《遗传》, 《中国生物化学与分子生物学报》    

     

编辑(Editorial    

客座副编辑(Guest Associate Editor):PLOS Genetics (2022), Frontiers in Endocrinology (2022)《中国生物化学与分子生物学报》(2024    

     

研究概述    

蛋白质的翻译后修饰(包括磷酸化、泛素化以及O-GlcNAc糖基化)参与有丝分裂DNA 损伤修复以及自噬的机制研究,及其与人类疾病的关系。    

     

Research Description

Mechanistic studies of protein post-translational modifications (PTMs), e.g. phosphorylation, ubiquitination and O-GlcNAc glycosylation, involved in the process of cell cycle, the DNA damage repair network (DDR), as well as in autophagy, with particular emphasis on its relationship with human diseases.

     

Publications (Corresponding *) (第一/通讯25篇,其中Nature Index 8)

     

2024

1.             Jie Li1, Wen Zhou1, Jianzhi Zhang1, Li Ma1, Zhuan Lv, Yiqun Geng*, Xing Chen* and Jing Li*. 2024. O-GlcNAcylation of YTHDF2 antagonizes ERK-dependent phosphorylation

   and inhibits lung carcinoma. BioRxiv. doi: 10.1101/2023.09.09.557012

2.             Xiaolu Ma1, Hui Fu1, Chenyi Sun1, Wei Wu1, Wenya Hou1, Zibin Zhou, Hui Zheng, Yifei Gong, Honglin Wu, Junying Qin, Huiqiang Lou, Jing Li*,Tie-Shan Tang* and Caixia Guo*. 2024 RAD18 O-GlcNAcylation promotes translesion DNA synthesis and homologous recombination repair. Cell Death & Diseases submitted

3.             Zibin Zhou1, Xiyuan Zheng1, Jianxin Zhao1, Aiyun Yuan1, Guangcan Shao, Zhuan Lv, Bin Peng, Meng-Qiu Dong, Quan Xu*, Xingzhi Xu* and Jing Li*. 2024 ULK1-dependent phosphorylation of PKM2 antagonizes O-GlcNAcylation and inhibits breast cancer. Oncogene (TOP) revision

4.             Jianxin Zhao1, Jie Hua1, Yahui Zhan1, Chunxu Chen1, Jie Li, Yue Liu, Liqian Yang, Haiying Wang*, Hengbin Wang* and Jing Li*. 2024 O-GlcNAcylation stimulates the deubiquitination activity of USP16 and regulates cell cycle progression. Journal of Biological Chemistry(TOP) revision

5.             Lulu Chen1,*, Mengxue Hu1, Luojun Chen, Yihan Peng, Cai Zhang, Xiangpan Li, Yi Yao, Qibin Song, Jing Li* and Huadong Pei* Targeting O-GlcNAcylation in Cancer Therapeutic Resistance: The Sugar Saga Continues. 2024 Cancer Letters (TOP) submitted

6.             Chen Wu1, *, Jiaheng Li1, Lingzi Lu1, Mengyuan Li, Yanqiu Yuan* andJing Li*. 2024. OGT and OGA: Sweet Guardians of the Genome Journal of Biological Chemistry (TOP) (Invited) submitted

7.             Jie Li, Guangcan Shao, Bin Peng, Xingzhi Xu, Meng-Qiu Dong and Jing Li* The role of Polo-like kinase 1 (PLK1) O-GlcNAcylation in mitosis 2024 Methods in Molecular Biology (invited) Accepted

8.             Annan Ming1, Jianxin Zhao1, Yihan Liu, Yibo Wang, Xiaohui Wang*, Jing Li* and Leiliang Zhang*. 2024 O-glycosylation in Viruses: A Sweet Tango. mLife(invited) Accepted

     

2023

1.             Jie Li1, Xiangxiang Liu1, Bin Peng1, Tingting Feng1, Wen Zhou, Li Meng, Shanshan Zhao, Xiyuan Zheng, Chen Wu, Shian Wu, Xing Chen, Xingzhi Xu*, Jianwei Sun* and Jing Li* 2023 O-GlcNAc has crosstalk with ADP-ribosylation via PARG. Journal of Biological Chemistry. (TOP) 299(11):105354

2.             Mengyao Li1, Jie Li1, Yibo Wang1, Jianxin Zhao, Aiyun Yuan, Weidong Dong, Linlin Kong, Suwei Dong, Weijie Qin, Yun-Gui Yang, Xiaohui Wang*, Chen Wu* and Jing Li* 2023 DNA damage-induced YTHDC1 O-GlcNAcylation promotes homologous recombination by enhancing m6A binding. Fundamental ResearchDOI: 10.1016/j.fmre.2023.04.017

3.             Ningda Xu1, Yi Cai1, Jiarui Li, Tianchang Tao, Caifei Liu, Yan Shen, Xiaoxin Li, Leiliang Zhang, Mingwei Zhao, Xuan Shi*, Jing Li* and Lvzhen Huang*. 2023 An SNX31 variant underlies dominant familial exudative vitrieoretinopathy like pathogenesis. JCI Insight 8(10):e167032 (TOP)

4.             Jie Li1, Muhammad Ahmad1, Lei Sang1, Yahui Zhan1, Yibo Wang, Yonghong Yan, Yue Liu, Weixiao Mi, Mei Lu, Yu Dai, Rou Zhang, Meng-Qiu Dong, Yun-Gui Yang, Xiaohui Wang*, Jianwei Sun*, and Jing Li* 2023 O-GlcNAcylation promotes the cytosolic localization of the m6A reader YTHDF1 and colorectal cancer tumorigenesis. Journal of Biological Chemistry. 299(6):104738 (TOP)

5.             Ying Tian1, Tao Zhang1, Jing Li and Yong Tao* 2023 Advances in development of exosomes for ophthalmic therapeutics. Advanced Drug Delivery Review 199:114899 (invited) (TOP)    

6.             Sheng Yan1, Bin Peng1, Shifeng Kan1, Guangcan Shao, Xiangyan Tang, Yong-Xiang Chen, Meng-Qiu Dong, Xiao Liu*, Xingzhi Xu* and Jing Li* 2023 Polo-like kinase 1 (PLK1) O-GlcNAcylation is essential for dividing mammalian cells and inhibits uterine carcinoma. Journal of Biological Chemistry. 299(2) :102887 (TOP)

     

2022

1.           Sheng Yan and Jing Li* 2022 Ulk1 in autophagy: Sugar it up. Autophagy Reports 1:1, 567-569

2.           Jie Wu; Cong Lei; Xilong Li; Xueyang Dong; Ke Qin; Weiyao Hong; Jing Li; Yuntao Zhu*; Xing Chen*. 2022 Chemoproteomic Profiling of O-GlcNAcylation in Arabidopsis Thaliana by Using Metabolic Glycan Labeling. Israel Journal of Chemistrye202200065

3.           Ningda Xu1, Yue Liu1, Shanshan Nai1, Yong Tao1, Yuehe Ding, Lemei Jia, Qizhi Geng, Jie Li, Yujing Bai, Gong-Hong Wei, Meng-Qiu Dong, Linyi Luo, Mingwei Zhao, Xingzhi Xu, Xiao-Xin Li*, Jing Li* and Lvzhen Huang* 2022. UBE3D is involved in blue light-induced retinal damage by regulating double-strand break repair. Investigative Ophthalmology & Visual ScienceIOVS 63(10):7 (TOP)      

4.           Yingxin Shi1, Sheng Yan1, Guang-Can Shao1, Jinglong Wang, Yong-Ping Jian, Bo Liu, Yanqiu Yuan, Ke Qin, Shanshan Nai, Xiahe Huang, Yingchun Wang, Zhenghui Chen, Xing Chen, Meng-Qiu Dong, Yiqun Geng*, Zhi-Xiang Xu* and Jing Li* 2022 O-GlcNAcylation stabilizes the autophagy-initiating kinase ULK1 by inhibiting chaperone-mediated autophagy upon HPV infection. Journal of Biological Chemistry. 298(9):102341. (TOP)    

        5.               Yanfang Chen, Guang-Can Shao, Jie Li, An-Qi Yang, Jing Li and Xinshan Ye* 2022 O-GlcNAcylation of Blimp-1 in Lymphocytes Inhibits Its Transcriptional Function and Is Associated with Migration and Invasion of Breast Cancer Cells. Molecular Cancer Research, 20(4):650-660    

6.           Jing-Jing Zhu1, Yanfang Chen1,Jing Li, and Xin-Shan Ye*. 2022 O-GlcNAcylation increases PYGL activity by promoting phosphorylation. Glycobiology 32(2):101-109

     

1.             Aiyun Yuan1, Xiangyan Tang1 and Jing Li* 2021 Centrosomes: Til O-GlcNAc do us apart. Frontiers in Endocrinology 11:621888    

2.             李静*,谭忠平 2020 葡糖酰胺(O-GlcNAc)修饰:细胞内糖基化的前世今生 《中国生物化学与分子生物学报》 (特约综述)36(9): 987-1001

3.             Bo Ma, Xiaoyang Guan, Yaohao Li, Shiying Shang, Jing Li* and Zhongping Tan*. 2020 Protein glycoengineering: An approach for improving protein properties. Frontiers in Chemistry.8:622

4.             Caifei Liu1, Yingxin Shi1, Jie Li1, Xuewen Liu, Zhikai Xiahou, Zhongping Tan, Xing Chen and Jing Li*. 2020 O-GlcNAcylation of myosin phosphatase targeting subunit 1 (MYPT1) dictates timely disjunction of centrosomes. Journal of Biological Chemistry. 295(21):7341-7349 (TOP)

5.             Fu-Cheng Wang, Bin Peng, Sheng-Li Cao, Hong-Yun Li, Xiao-Li Yuan, Ting-Ting Zhang, Ruifeng Shi, Zhuqing Li, Ji Liao, Hailong Wang, Jing Li and Xingzhi Xu*. 2020 Synthesis and cytotoxic activity of chalcone analogues containing a thieno[2,3-d]pyrimidin-2-yl group as the A-ring or B-ring. Bioorganic Chemistry 10:103346(TOP)

6.             Shanshan Nai1, Yingxin Shi1, Huanwei Ru1, Yuehe Ding, Qizhi Geng, Zhe Li, Meng-Qiu Dong, Xingzhi Xu and Jing Li* 2019 Chk2-dependent phosphorylation of myosin phosphatase targeting subunit 1 (MYPT1) regulates centrosome maturation. Cell Cycle 18(20):2651-2659

7.             Xue Han1, Bin Peng1, Bei-Bei Xiao1, S.-Li Cao*, Chao-Rui Yang, Wen-Zhu Wang, Fu-Cheng Wang, Hong-Yun Li, Xiao-Li Yuan, Ruifeng Shi, Ji Liao, Hailong Wang, Jing Li, Xingzhi Xu*. 2019 Synthesis and evaluation of chalcone analogues containing a 4-oxoquinazolin-2-yl group as potential anti-tumor agents. European Journal of Medicinal Chemistry. 162:586-601(TOP)    

8.             Caifei Liu and Jing Li* 2018 O-GlcNAc: a sweetheart of the cell cycle and DNA damage response. Frontiers in Endocrinology(Invited) 9:415.[ O-GlcNAcylation: expanding the frontiers (eBook , 2020): ISSN 1664-8714; ISBN 978-2-88963-425-5; DOI 10.3389/978-2-88963-425-5]

9.             Xiaomei Hu1, Zhe Li1, Yuehe Ding, Qizhi Geng, Zhikai Xiahou, Huanwei Ru, Meng-Qiu Dong, Xingzhi Xu and Jing Li*. 2018 Chk1 modulates the interaction between myosin phosphatase targeting protein 1 (MYPT1) and protein phosphatase 1cβ (PP1cβ). Cell Cycle. 17 (4): 421–427

10.         Chao-rui Yang1, Bin Peng1, Sheng-Li Cao*, Ting-ting Ren, Wei Jiang, Fu-Cheng Wang, You-Shan Li, Guo Wang, Zheng Li, Shibin Xu, Ji Liao, Hailong Wang, Jing Li, Xingzhi Xu*. 2018. Synthesis, cytotoxic evaluation and target identification of thieno[2,3-d]pyrimidine derivatives with a dithiocarbamate side chain at C2 position. European Journal of Medicinal Chemistry, 154: 324-340(TOP)

11.         Xiaolu Ma1, Hongmei Liu1, Jing Li1,Yihao Wang, Yuehe Ding, Hongyan Shen, Yeran Yang, Chenyi Sun,Min Huang, Yingfeng Tu,Yang Liu,Yongliang Zhao, Mengqiu Dong, Ping Xu, Tie-Shan Tang*,  Caixia Guo*2017 Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis. Nature Communications. 8(1):1941. (1 Equal Contributions) (TOP)    

12.         Jie Tian1, Yingxing Shi1, Shanshan Nai, Qizhi Geng, Lei-Liang Zhang, Gong-Hong Wei, Xingzhi Xu* and Jing Li*. 2017. Ataxin-10 is involved in Golgi membrane dynamics.Journal of Genetics and Genomics. 44(11):549-552

13.         Zhe Li1Xueyan Li1Shanshan Nai, Qizhi Geng, Ji Liao, Xingzhi Xu* and Jing Li*. 2017 Checkpoint kinase 1-induced phosphorylation of O-Linked β-N-Acetylglucosamine transferase regulates the intermediate filament network during cytokinesis. Journal of Biological Chemistry. 292(48) 19548–19555 (TOP)    

14.         Xueyan Li, Shanshan Nai, Yuehe Ding, Qizhi Geng, Bingtao Zhu, Kai Yu, Wei-Guo Zhu, Meng-Qiu Dong, Xiao-Dong Su, Xingzhi Xu*and Jing Li*. 2017 Polo-like kinase 1 (PLK1)-dependent phosphorylation of methylenetetrahydrofolate reductase (MTHFR) regulates replication via histone methylation.Cell Cycle 16(20):1933-1942

15.         Li YS, Peng B, Ma L, Cao SL, Bai LL, Yang CR, Wan CQ, Yan HJ, Ding PP, Li ZF, Liao J, Meng YY, Wang HL, Li J, Xu X. 2017 Synthesis, crystal structures and antitumor activity of two platinum(II) complexes with methyl hydrazinecarbodithioate derivatives of indolin-2-one. Eur J Med Chem. 127:137-146. (TOP)    

16.         Jing Li* and Xingzhi Xu*. 2016 DNA double-strand break repair: a tale of pathway choices. Acta Biochimica et Biophysica Sinica. 48(7):641-6.    

17.         Jie Tian1, Qizhi Geng1, Yuehe Ding, Ji Liao, Meng-Qiu Dong, Xingzhi Xu* and Jing Li*. 2016 O-GlcNAcylation antagonizes phosphorylation of Cdh1 (CDC20 homologue 1). Journal of Biological Chemistry. 291(23):12136-44. (TOP)

18.         Ding PP, Gao M, Mao BB, Cao SL, Liu CH, Yang CR, Li ZF, Liao J, Zhao H, Li Z, Li J, Wang H, Xu X. 2016.Synthesis and biological evaluation of quinazolin-4(3H)-one derivatives bearing dithiocarbamate side chain at C2-position as potential antitumor agents. Eur J Med Chem. 108:364-73(TOP)

19.         ­­­­­­Jie Tian, Chuan Tian, Yuehe Ding, Zhe Li, Qizhi Geng, Zhikai Xiahou, Jue Wang, Wenya Hou, Ji Liao, Meng-Qiu Dong, Xingzhi Xu* and Jing Li*. 2015 Aurora B-dependent phosphorylation of Ataxin-10 promotes the interaction between Ataxin-10 and Plk1 in cytokinesis. Scientific Reports.5:8360

20.         Zhao H, Zhu M, Dou G, Zhao H, Zhu B, Li J, Liao J, Xu X. BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response. 2014 Cell Cycle. 13(11):1777-87.

21.         Jing Li1,*, Xiaoqian Liu1, Ji Liao, Jie Tian, Jue Wang, Xin Wang, Jiezhong Zhang and Xingzhi Xu*. 2013. MYPT1 sustains centromeric cohesion and the spindle-assembly checkpoint. Journal of Genetics and Genomics. 40(11):575-8.    

22.         Jinping Liu, Linli Xu, Jianing Zhong, Ji Liao, Jing Li and Xingzhi Xu. 2012. Protein phosphatase PP4 is involved in NHEJ-mediated repair of DNA double-strand breaks. Cell Cycle 11(14), 2643-49 (Commentary on Cell Cycle 11(14), 2590)

23.         Jinping Liu, Shukun Luo, Hongchang Zhao, Ji Liao, Jing Li, Chunying Yang, Bo Xu, David F. Stern, Xingzhi Xu* and Keqiong Ye*. 2012. Structural mechanism of the phosphorylation-dependent dimerization of MDC1 forkhead-associated domain. Nucleic Acids Research 40(9):3898-3912 (featured article) (TOP)

24.         Li J1,*., Wang, J1., Hou, W1., Jing, Z., Tian, C., Han, Y., Liao, J., Dong, M-Q., Xu, X*. 2011. Phosphorylation of Ataxin-10 by polo-like kinase 1 is required for cytokinesis. Cell Cycle 10(17):2946 – 2958 (cover article)

25.         Zhong J, Liao J, Liu X, Wang P, Liu J, Hou W, Zhu B, Yao L, Wang J, Li J, Stark JM, Xie Y, Xu X. 2011 Protein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaks. Cell Cycle 10(9):1411-1419    

26.         Lv, S., Bu, W., Jiao, H., Liu, B., Zhu, L., Zhao, H., Li, J., Liao, J., Xu, X. 2010. LSD1 is required for chromosome segregation during mitosis. Eur. J. Cell Biol. 89(7):557-63    

        27.             Li, J*., Wang, J., Jiao, H., Liao, J., and Xu, X*. 2010. Cytokinesis and cancer: Polo loves ROCK’n’Rho(A). Journal of Genetics and Genomics 37 (3):159-172

 

28.         Wang, H., Zhao, A., Chen, L., Zhong, X., Liao, J., Gao, M., Cai, M., Lee, D.H., Li, J., Chowdhury, D., Yang, Y.G., Pfeifer, G.P., Yen, Y., and Xu, X. 2009. Human RIF1 encodes an anti-apoptotic factor required for DNA repair. Carcinogenesis 30(8):1314-1319

29.         Zhang, X., Liu, D., Lv, S., Wang, H., Zhong, X., Liu, B., Wang, B., Liao, J., Li, J., Pfeifer G. P., and Xu, X. 2009. CDK5RAP2 is required for spindle checkpoint function. Cell Cycle 8(8): 1206-1216.

30.         Wang, B., Zhao, A., Sun, L., Zhong, X.. Zhong, J., Wang, H., Cai, M., Li, J., Xu, Y., Liao, J., Sang, J., Chowdhury, D., Pfeifer, G.P., Yen, Y., and Xu, X. 2008. Protein phosphatase PP4 is overexpressed in human breast and lung tumors. Cell Research 18:974-977 (TOP)

31.         Li, J., Agarwal, S., and Roeder, G.S. 2007 SSP2and OSW1, Two sporulation-specific genes involved in spore morphogenesis in Saccharomyces cerevisiae. Genetics. 175(1):143-154 (TOP)

32.         Li, J., Hooker, G.W., and Roeder, G.S. 2006. Saccharomyces cerevisiae Mer2, Mei4 and Rec114 form a complex required for meiotic double-strand break formation. Genetics, 173(4): 1969-1981 (TOP)

33.         Huafei Lu, Xiaotian Ming, Lijia Qu, Meihua Liu, Jing Li, Hongya Gu, Zhangliang Chen. 2000. Construction of chimeric inducible promoters by elicitors of rice fungal blast pathogen and their expression in transgenic rice. Chinese Science Bulletin, 45(3):242-246